Molecular Biology Select
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چکیده
Diffusible signals in plants spread RNA silencing from tissue to tissue over both short and long distances, but how does RNA interference in plants spread over long distances? In a recent paper, Molnar et al. (2010) observe that 24 nucleotide small RNAs in the model plant Arabidopsis thaliana are transported in phloem between shoots and roots and once at their destinations have the ability to direct epigenetic change in recipient cells. The study cleverly uses grafts between wild-type plants and plants with impaired small RNA biogenesis and high-throughput sequencing technologies to demonstrate that multiple sizes of small RNAs are mobile. These include 21 nucleotide miRNAs and 21 to 24 nucleotide small-interfering RNAs (siRNAs). The 24 nucleotide siRNAs are known to mediate RNA-directed DNA methylation, and this is confirmed by assessment of methylation at three target loci in the recipient tissue. Intriguingly, the 24 nucleotide siRNAs also appear to be more frequent in the pool of mobile RNAs than the other classes. Understanding the reasons why they are enriched could shed light on the mechanisms that regulate the production and transport of mobile small RNAs. These efforts also lay the groundwork for the discovery of new physiological roles for the transmission of epigenetic modifications between distant tissues. A. Molnar et al. (2010). Science. Published online April 22, 2010. 10.1126/science.1187959.
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عنوان ژورنال:
- Cell
دوره 141 شماره
صفحات -
تاریخ انتشار 2010